Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency
M. B. Borror, M. Girotti, A. Kar, M. Cain, X. Gao, V. MacKay, B. Herron, S. Bhaskaran, S. Becerra, N. Novy, N. Ventura, T. E. Johnson, B. L. Kennedy, S. L. Rea
This study shows that inhibiting ATR in C. elegans reduces the severity of mitochondrial ETC dysfunction by reversing nucleotide imbalances and restoring translation.
bioRxiv · Oct 22, 2019Pathology