Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit
L. Crozier, R. Foy, R. Adib, M. Badonyi, A. Kar, J. A. Holt, R. Wilson, C. Regnault, P. Whitfield, J. A. Marsh, A. T. Saurin, A. R. Barr, T. Ly
The paper shows that CDK4/6 inhibitor-induced G1 arrest causes cell overgrowth, triggering osmotic stress and p38-p53-p21 signaling to promote cell cycle exit.
bioRxiv · Sep 8, 2022Cell Biology