Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma
B. Hilvering, T. S. Hinks, L. Stoger, E. Marchi, M. Salimi, R. Shrimanker, W. Liu, W. Chen, J. Luo, S. Go, T. Powell, J. Cane, S. Thulborn, A. Kurioka, T. Leng, , L. Xue
The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.
bioRxiv · Jan 12, 2018Immunology