Author

T. Leng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:deep learning· 2 Assay:proteomics· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. Klenerman· 3 shared A. Kurioka· 2 shared C. Willberg· 2 shared E. Marchi· 2 shared M. N. Alam· 2 shared S. Gholami· 2 shared A. Ahsaniyan· 1 shared A. B. Brueggemann· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

P. Klenerman

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Author profile →

5 papers

Recent·Most cited

EYE-Llama, an in-domain large language model for ophthalmology

t. haghighi, S. Gholami, J. T. Sokol, E. Kishnani, A. Ahsaniyan, H. Rahmanian, F. Hedayati, T. Leng, M. N. Alam

This paper introduces EYE-Llama, an ophthalmology-specific large language model trained on in-domain data, which outperforms baseline models in medical question-answering tasks.

bioRxiv · Apr 26, 2024Bioengineering

Federated learning for diagnosis of age-related macular degeneration

S. Gholami, J. I. Lim, T. Leng, S. S. Y. Ong, A. C. Thampson, M. N. Alam

This paper develops a federated learning approach for AMD diagnosis using OCT images, showing that adaptive personalization FL achieves high performance with decentralized data.

bioRxiv · Jul 6, 2023 · PreprintBioengineering

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

T. Leng, H. Delowar Akther, C.-P. Hackstein, T. King, M. Friedrich, Z. Christoforidou, S. McCuaig, M. Neyazi, C. V. Arancibia-Carcamo, F. Powrie, Oxford IBD Investigators, E. Marchi, R. Sanchesperes, V. Millar, D. Ebner, , P. Klenerman

This study investigates how TCR and inflammatory signals shape human MAIT cell functions, revealing their roles in tissue repair and effector responses.

bioRxiv · May 14, 2019Immunology

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

B. Hilvering, T. S. Hinks, L. Stoger, E. Marchi, M. Salimi, R. Shrimanker, W. Liu, W. Chen, J. Luo, S. Go, T. Powell, J. Cane, S. Thulborn, A. Kurioka, T. Leng, , L. Xue

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.

bioRxiv · Jan 12, 2018Immunology

Diverse Streptococcus pneumoniae strains drive a MAIT cell response through MR1-dependent and cytokine-driven pathways

A. Kurioka, B. van Wilgenburg, R. R. Javan, R. Hoyle, A. J. van Tonder, C. L. Harrold, T. Leng, L. J. Howson, D. Shepherd, V. Cerundolo, A. B. Brueggemann, P. Klenerman

This study shows that diverse Streptococcus pneumoniae strains activate MAIT cells via MR1-dependent and cytokine-driven pathways, with conserved riboflavin operon genes across strains.

bioRxiv · Jul 17, 2017Immunology