L. Xue

Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation

This study identifies SPARCL1 as a pro-inflammatory mediator secreted by endothelial cells that worsens viral pneumonia by promoting macrophage activation and is elevated in severe COVID-19 cases.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Multi-faceted roles of β-arrestins in G protein-coupled receptors endocytosis

The paper challenges the conventional view of GPCR internalization by showing multiple pathways regulate receptor internalization, with specific findings on the GLP-1R's mechanism.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

JAZF1 is transcriptionally regulated by SOX11 and promotes cardiac fibrosis by PI3K-Akt pathway

This study shows JAZF1 is regulated by SOX11 and promotes cardiac fibrosis via the PI3K-Akt pathway in a rat model.

CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19

The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.

Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells

This study uses cryo-electron tomography to show how chloramphenicol affects ribosome structure and translation in Mycoplasma pneumoniae, revealing context-dependent inhibition mechanisms.

GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells

The paper uses proximity mapping to show AMPK regulates GLUT4 subcellular localization in muscle cells by controlling exocytosis and endocytosis.

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

Liposome-assisted in-situ cargo delivery to artificial cells and cellular subcompartments

This paper demonstrates liposome-mediated delivery of cargo into artificial cells, enabling enzymatic reactions and gene expression with high efficiency and precision.

Activation of the chemokine receptor CCR1 and preferential recruitment of Gαi suppress RSV replication: implications for developing novel RSV treatment strategies

This study shows that CCR1 activation on respiratory epithelial cells suppresses RSV replication via Gi-mediated inhibition of STAT3 phosphorylation and HSP90 activity, independent of IFN-I.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Visualizing translation dynamics at atomic detail inside a bacterial cell

This study uses cryo-electron tomography to visualize translation dynamics in Mycoplasma pneumoniae, revealing ribosome states and showing how antibiotics affect translation.

Transport among protocells via tunneling nanotubes

The paper demonstrates molecular transport between protocells via lipid nanotubes, suggesting a potential prebiotic communication mechanism.

Locating Macromolecular Assemblies in Cells by 2D Template Matching with cisTEM

This paper introduces a GPU-accelerated 2D template matching method in cisTEM for identifying macromolecular assemblies in cells, demonstrating its utility for in situ proteomics and structure determination.

Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag and CLIP-tag

The paper compares the labeling kinetics and substrate specificities of HaloTag7, SNAP-tag, and CLIP-tag to guide their optimal use in bioimaging and biotechnology.

Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.7 A inside cells

The paper introduces a software tool, M, for multi-particle cryo-EM refinement that achieves 3.7 Å resolution of a ribosome-antibiotic complex inside bacterial cells.

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

Two antagonistic effect genes mediate separation of sexes in a fully dioecious plant

The paper identifies two genes in Populus deltoides that antagonistically regulate sex determination by repressing female structures and promoting male structures through epigenetic and RNA-based mechanisms.

Rapid growth and fusion of protocells in surface-adhered membrane networks

This study shows that moderate temperature increases promote the rapid growth and fusion of protocells formed from lipid networks on solid surfaces, enabling RNA encapsulation and redistribution.

Correlation of p53 and DNA repair gene mutation patterns in human malignancies indicates different tumour suppression mechanisms of p53

The paper analyzes mutation patterns of p53 and DNA repair genes in human cancers to identify differences in p53's tumor suppression mechanisms across cancer types.

A general strategy to develop cell permeable and fluorogenic probes for multi-colour nanoscopy

The paper develops a strategy to create fluorogenic probes for live-cell nanoscopy with high cell permeability and low background signal.

Impact of fruit-tree shade intensity on the growth, yield, and quality of intercropped wheat

This study examines how different fruit tree shade intensities affect wheat growth, yield, and quality in intercropping systems, finding that shade reduces yield components but increases protein content and dough properties.

Type-2 CD8+ T lymphocytes responsive to PGD2 and LTE4 in severe eosinophilic asthma

The paper identifies type-2 CD8+ T cells (Tc2) enriched in severe eosinophilic asthma and shows PGD2 and LTE4 drive their recruitment and activation, contributing to eosinophilia.