BiochemistrybioRxiv
Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases
P. Mohanty, Rashmi, B. I. Habibullah…·R. Das
This study shows that deamidation of UBC13 by OspI disrupts native and transient interactions with TRAF6RING, inhibiting their complex formation and downstream NF-κB signaling.
DOI 10.7554/elife.49223