Author

S. Sunyaev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:Arabidopsis· 2 Assay:DNA methylation· 2 Research Focus:GWAS / association mapping· 2 Assay:whole-genome sequencing· 2 Research Focus:development & morphogenesis· 1 Organism:E. coli· 1 Organism:human· 1

Frequent Co-Authors

E. Koch· 3 shared J. de Meaux· 2 shared A. Sloutsky· 1 shared B. de Jong· 1 shared B. J. Arnold· 1 shared B. Wieters· 1 shared C. J. Meehan· 1 shared C. Wadsworth· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersEvolutionary Biology

E. Koch

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5 papers

Recent·Most cited

Recurrent mutation in the ancestry of a rare variant

J. Wakeley, W. T. Fan, E. Koch, S. Sunyaev

The paper develops a statistical model to account for recurrent mutations in the ancestry of rare variants and applies it to human SNP data to explain differences in site-frequency spectra across mutation rates.

bioRxiv · Aug 18, 2022Evolutionary Biology

Maintenance of adaptive dynamics and no detectable load in a range-edge out-crossing plant population

M. Takou, T. Hämälä, E. Koch, K. A. Steige, H. Dittberner, L. Yant, M. Genete, S. Sunyaev, V. Castric, X. Vekemans, O. Savolainen, J. de Meaux

The paper examines a range-edge population of Arabidopsis lyrata ssp petraea and finds it maintains adaptive dynamics and no detectable fitness load despite genetic drift and increased genomic burden of deleterious mutations.

bioRxiv · Nov 9, 2020Evolutionary Biology

Polygenic adaptation of rosette growth in Arabidopsis thaliana populations

B. Wieters, K. Steige, F. He, E. Koch, S. Ramos-Onsins, H. Y. Gu, Y. Guo, S. Sunyaev, J. de Meaux

This study investigates the genetic and environmental factors influencing growth rate variation in Arabidopsis thaliana, finding polygenic adaptation and environmental plasticity as key drivers.

bioRxiv · Mar 31, 2020Evolutionary Biology

Fine-scale haplotype structure reveals strong signatures of positive selection in a recombining bacterial pathogen

B. J. Arnold, M. Sohail, C. Wadsworth, J. Corander, W. P. Hanage, S. Sunyaev, Y. Grad

The paper identifies strong signatures of positive selection in Neisseria gonorrhoeae by analyzing fine-scale haplotype structure and linkage patterns between nonsynonymous alleles.

bioRxiv · May 10, 2019Evolutionary Biology

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

M. R. Farhat, L. Freschi, R. Calderon, T. Ioerger, M. Snyder, C. J. Meehan, B. de Jong, L. Rigouts, A. Sloutsky, D. Kaur, S. Sunyaev, D. van Soolingen, J. Shendure, J. Sacchettini, M. Murray

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.

bioRxiv · Oct 1, 2018Evolutionary Biology