Author

S. Zaccaria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:clustering· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. J. Raphael· 2 shared A. C. Gross· 1 shared A. L. Kung· 1 shared A. Makohon-Moore· 1 shared B. Arnold· 1 shared B. J. Arnold· 1 shared C. A. Iacobuzio-Donahue· 1 shared C. Cobbs· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

B. J. Raphael

Mutual co-authors in cluster

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3 papers

Recent·Most cited

HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data

M. A. Myers, B. J. Arnold, V. Bansal, K. M. Mullen, S. Zaccaria, B. J. Raphael

HATCHet2 improves copy number inference from bulk tumor sequencing by identifying clone- and haplotype-specific aberrations, revealing new mirrored-subclonal CNAs in prostate cancer.

bioRxiv · Jul 13, 2023Cancer Biology

Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

M. D. Kinnaman, S. Zaccaria, A. Makohon-Moore, B. Arnold, M. Levine, G. Gundem, J. E. A. Ossa, D. Glodzik, M. I. R. Sanchez, N. Bouvier, S. Li, E. Stockfisch, M. Dunigan, C. Cobbs, U. Bhanot, , C. A. Iacobuzio-Donahue

This study identifies subclonal copy number alterations in relapsed osteosarcoma, showing MYC gain/amplification in treatment-resistant clones and their emergence before chemotherapy.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

Structurally complex osteosarcoma genomes exhibit limited heterogeneity within individual tumors and across evolutionary time

S. Rajan, S. Zaccaria, M. V. Cannon, M. Cam, A. C. Gross, B. J. Raphael, R. D. Roberts

This study analyzes SCNAs in osteosarcoma using single-cell DNA sequencing, finding limited heterogeneity and suggesting early catastrophic events drive genomic complexity.

bioRxiv · Aug 30, 2021Cancer Biology