Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages
S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee, B. Bhattacharya, E. Wood, M. Kasaikina, B. Kholodenko, A. A. Gimelbrant, I. Kramnik
The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.
bioRxiv · Feb 9, 2023 · PreprintImmunology