Author

B. Bhattacharya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

I. Kramnik· 4 shared S. Chatterjee· 4 shared L. Kobzik· 3 shared S. M. Yabaji· 3 shared O. S. Rukhlenko· 2 shared W. Bishai· 2 shared A. A. Gimelbrant· 1 shared A. B. Beeler· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

I. Kramnik

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

S. Malik, J. Biswas, P. Sarkar, S. Nag, C. Gain, S. Ghosh Roy, B. Bhattacharya, D. Ghosh, A. Saha

This study shows that differential carbonic anhydrase activities regulate EBV-induced B-cell transformation and lytic cycle reactivation through transcriptional control by EBNA2 and BZLF1.

bioRxiv · Sep 8, 2023Microbiology

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee, B. Bhattacharya, E. Wood, M. Kasaikina, B. Kholodenko, A. A. Gimelbrant, I. Kramnik

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

bioRxiv · Feb 9, 2023 · PreprintImmunology

Supervised Machine Learning Enables Geospatial Microbial Provenance

C. Bhattacharya, B. T. Tierney, K. A. Ryon, M. Bhattacharyya, J. J. A. Hastings, S. Basu, B. Bhattacharya, D. Bagchi, S. Mukherjee, L. Wang, E. M. Henaff, C. Mason

This study uses supervised machine learning to identify microbial fingerprints in urban and oceanic environments, achieving high accuracy in location classification.

bioRxiv · Sep 16, 2022Microbiology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology

Channeling macrophage polarization via selective translation inhibition by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

S. Chatterjee, S. M. Yabaji, B. Bhattacharya, E. Waligurski, N. Vallavoju, S. Ray, L. E. Brown, A. B. Beeler, A. R. Ivanov, L. Kobzik, J. A. Porco, I. Kramnik

This study shows rocaglates shift macrophage polarization toward M1-like by inhibiting IL-4 response and enhancing resistance to Mycobacterium tuberculosis.

bioRxiv · Aug 31, 2020 · PreprintImmunology

The integrated stress response mediates type I interferon driven necrosis in Mycobacterium tuberculosis granulomas

B. Bhattacharya, S. Xiao, S. Chatterjee, M. Urbanowski, A. Ordonez, E. A. Ihms, G. Agrahari, S. Lun, R. Berland, A. Pichugin, Y. Gao, J. Connor, A. Ivanov, B.-S. Yan, L. Kobzik, , I. Kramnik

This study identifies the integrated stress response (ISR) as a mediator of necrosis in tuberculosis granulomas, showing that ISR inhibition reduces bacterial burden and necrosis in susceptible mice.

bioRxiv · Dec 19, 2018 · PreprintImmunology