Author

O. S. Rukhlenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. Bhattacharya· 2 shared B. N. Kholodenko· 2 shared I. Kramnik· 2 shared S. Chatterjee· 2 shared S. M. Yabaji· 2 shared A. A. Gimelbrant· 1 shared A. Gimelbrant· 1 shared A. Tuliakova· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

B. Bhattacharya

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 24, 2023

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

H. Deng, O. S. Rukhlenko, D. Joshi…·M. A. Schwartz

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

DOI 10.1101/2023.10.24.563764

mousescRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 9, 2023

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

S. M. Yabaji, O. S. Rukhlenko, S. Chatterjee…·I. Kramnik

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

DOI 10.1101/2023.02.09.527908

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 14, 2020

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov…·I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

DOI 10.1101/2020.12.14.422743

mouseexperimental assay

𝕏 PostBluesky