Author

B. L. Fridley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:human· 2 Assay:spatial transcriptomics· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. C. Soupir· 2 shared B. J. Manley· 2 shared O. E. Ospina· 2 shared P. A. Stewart· 2 shared A. E. Berglund· 1 shared A. R. Anderson· 1 shared C. M. M. Segura· 1 shared C. M. Wilson· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

A. C. Soupir

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Author profile →

3 papers

Recent·Most cited

scSpatialSIM: a simulator of spatial single-cell molecular data

A. C. Soupir, J. Wrobel, J. H. Creed, O. E. Ospina, C. M. Wilson, B. J. Manley, L. C. Peres, B. L. Fridley

scSpatialSIM simulates spatial single-cell molecular data to evaluate spatial clustering methods, finding Ripleys K(r) best detects clustering across scenarios.

bioRxiv · Feb 8, 2024Cell Biology

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak, O. E. Ospina, N. H. Chakiryan, A. E. Berglund, P. A. Stewart, J. V. Nguyen, C. M. M. Segura, N. L. Francis, P. M. R. Echevarria, J. Chahoud, R. Li, K. Y. Tsai, J. A. Blasi, , B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

bioRxiv · Nov 16, 2023Cancer Biology

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

M. Damaghi, J. West, M. Robertson-Tessi, L. Xu, M. C. Ferrall-Fairbanks, P. A. Stewart, E. A. Persi, B. L. Fridley, P. M. Altrock, R. Gatenby, p. A. Sims, A. R. Anderson, R. J. Gillies

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

bioRxiv · Apr 7, 2020Cancer Biology