Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae
A. Muneer, L. Xie, X. Xie, F. Zhang, J. Wrobel, X. Yan, X. Yu, C. Wang, C. Gheorghe, P. Wu, J. Song, G.-L. Ming, J. Jin, H. Song, P.-Y. Shi, X. Chen
This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.
bioRxiv · Mar 4, 2024Immunology