Author

O. E. Ospina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Alhaddad· 2 shared I. Smalley· 2 shared K. Y. Tsai· 2 shared M. L. Khaled· 2 shared P. A. Forsyth· 2 shared P. A. Stewart· 2 shared Y. Ren· 2 shared A. C. Soupir· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

H. Alhaddad

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 18, 2023

Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease

M. L. Khaled, Y. Ren, R. Kundalia…·I. Smalley

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

DOI 10.1101/2023.12.18.572239

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivDec 18, 2023

Spatial transcriptomics analysis identifies a unique tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease

H. Alhaddad, O. E. Ospina, M. L. Khaled…·I. Smalley

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

DOI 10.1016/j.xcrm.2024.101606

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivNov 16, 2023

Increased spatial coupling of integrin and collagen IV in the immunoresistant clear cell renal cell carcinoma tumor microenvironment

A. C. Soupir, M. T. Hayes, T. C. Peak…·B. J. Manley

The paper uses spatial transcriptomics to identify increased spatial coupling of integrin and collagen IV in immunoresistant clear cell renal cell carcinoma tumors, suggesting integrin as a therapeutic target.

DOI 10.1186/s13059-024-03435-z

humanspatial transcriptomics

𝕏 PostBluesky