L. Xu

Human trunk embryoids with patterned anterior-posterior and dorsal-ventral body axes: utility for understanding human development and disease

The paper describes human trunk embryoids that mimic posterior trunk development and uses them to study developmental processes and disease mechanisms.

A small molecule VHL molecular glue degrader for cysteine dioxygenase 1

The paper identifies a small molecule that acts as a molecular glue degrader for CDO1 by recruiting it into the VHL E3 ligase complex, leading to its degradation.

A long non-coding RNA LINC00094 regulates the transcriptional expression of lipid metabolism-related genes as a new member of core regulatory circuitry in esophageal squamous cell carcinoma

This paper identifies LINC00094 as a long non-coding RNA that forms a core regulatory circuitry with TCF3 and KLF5 to regulate lipid metabolism-related genes in esophageal squamous cell carcinoma.

Deep mutational scanning reveals sequence to function constraints for SWEET family transporters

This study uses deep mutational scanning to analyze sequence-function relationships in the plant SWEET transporter AtSWEET13, identifying mutations that enhance transport function and revealing constraints in transmembrane helix 4.

Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor

This study shows that actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor, sensitizing anaplastic cells to treatment and improving survival in xenograft models.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

Bright New Resources for Syphilis Research: Genetically Encoded Fluorescent Tags for Treponema pallidum and Sf1Ep Cells

The paper introduces genetically encoded fluorescent tags for Treponema pallidum and Sf1Ep cells to enhance visualization and study host-pathogen interactions in syphilis research.

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

Oral Exposure to Benzalkonium Chlorides in Male and Female Mice Reveals Sex-Dependent Alteration of the Gut Microbiome and Bile Acid Profile

This study shows oral BAC exposure reduces gut microbiome diversity and secondary bile acids in female mice more than males.

Growth of Staphylococcus aureus in the presence of oleic acid shifts the glycolipid fatty acid profile and increases resistance to antimicrobial peptides

This study shows that oleic acid alters S. aureus membrane lipid composition, increasing resistance to antimicrobial peptides by changing biophysical properties.

Dehydrozaluzanin C- derivative protects septic mice by alleviating over-activated inflammatory response and promoting the phagocytosis of macrophages

DHZD reduces inflammation and enhances macrophage phagocytosis in septic mice, showing potential as an HDT agent for bacterial infections.

A delta-tubulin/epsilon-tubulin/Ted protein complex is required for centriole architecture

This study identifies a protein complex involving delta-tubulin, epsilon-tubulin, and TEDC1/2 that is essential for centriole architecture and function.

Proteolytic processing of both RXLR and EER motifs in oomycete effectors

The paper shows that RXLR and EER motifs in oomycete effectors are proteolytically processed before secretion, with cleavage sites constrained to specific positions.

Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in Caenorhabditis elegans

This study identifies two neuroendocrine circuits in C. elegans where nervous system signaling to the gut bidirectionally regulates lifespan depending on life stage.

The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin resistant Staphylococcus aureus

This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.

The impact of Bacillus coagulans X3 on available nitrogen content, bacterial community composition, and nitrogen functional gene levels when composting cattle manure

This study examines how adding Bacillus coagulans X3 to cattle manure compost affects nitrogen levels, bacterial communities, and nitrogen-related genes.

Several common methods of making vesicles (except an emulsion method) capture intended lipid ratios

This study compares lipid composition variations in vesicles made by five methods, finding significant differences in cholesterol and phospholipid ratios, particularly with emulsion transfer.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

Functional biogeography of marine microbial heterotrophs

The paper synthesizes genetic data with a marine ecosystem model to analyze functional biogeography of marine heteroprokaryotes, identifying key ecological factors shaping their distribution.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2

This study identifies BTN3A2 as a primate-specific gene that inhibits SARS-CoV-2 infection by reducing ACE2 expression and blocking viral attachment.

Potential pandemic risk of circulating swine H1N2 influenza viruses

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

Development of pre-clinical murine models for fibrolamellar hepatocellular carcinoma

This study develops a novel transgenic mouse model of fibrolamellar hepatocellular carcinoma (FLC) and highlights challenges in establishing ex vivo cell models from FLC tumors.

Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses

This paper determines the 3D structures of SL5 RNA domains from six coronaviruses, revealing conserved tertiary features with implications for protein-binding and antiviral targets.

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants

This study identifies immune programs linked to COVID-19 severity and mortality through longitudinal multi-omics analysis of 1,152 hospitalized patients.