GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
T. Gargett, L. M. Ebert, N. T. H. Truong, P. M. Kollis, K. Sedivakova, W. Yu, E. C. F. Yeo, N. L. Wittwer, B. L. Gliddon, M. N. Tea, R. Ormsby, J. Nowicki, S. Poonnoose, O. Vittorio, D. S. Ziegler, , M. P. Brown
This study demonstrates that GD2-targeting CAR-T cells, enhanced with IL-15 transgene expression, effectively control glioblastoma growth in a preclinical model and are clinically feasible.
bioRxiv · May 1, 2022Immunology