W. Yu

YAP/TAZ enhance P-body formation to promote tumorigenesis

This study shows YAP/TAZ promote P-body formation in cancer cells, enhancing tumorigenesis, and suggests targeting P-bodies or PNRC1 could be therapeutic.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

SLC13A2-transported citrate is a metabolic signal for PKM2 acetylation and degradation to suppress tumor growth

This paper identifies SLC13A2-transported citrate as a metabolic signal that promotes PKM2 acetylation and degradation, thereby suppressing tumor growth in hepatocellular carcinoma.

Hepatitis E virus infection upregulates ING5 expression in vitro and vivo

This study shows that HEV infection increases ING5 expression in both animal models and human cells, suggesting a potential role in HEV pathogenesis.

A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation

This study identifies how the bacterial effector RipE1 stabilizes by hijacking plant ubiquitin proteases and phosphorylation, avoiding degradation and promoting bacterial survival.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

Optically active, paper-based scaffolds for 3D cardiac tissue engineering

This paper presents a paper-based scaffold with gold nanorods and quantum dots for optical modulation of cardiac tissue in vitro, offering a high-resolution alternative to electrode-based methods.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

Antagonistic Roles of Tau and MAP6 in Regulating Neuronal Development

The paper shows tau and MAP6 have opposing roles in neuronal development by regulating microtubule stability and dynamics in cultured neurons and in vivo.

Dynamic Nature of Staphylococcus aureus Type I Signal Peptidases

This study uses molecular dynamics simulations to analyze the dynamic behavior of S. aureus Type I signal peptidases SpsA and SpsB, including the impact of the P29S mutation on their structure and function.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

Thermoplasmonic modulation of cardiomyocytes activity with local temperature read-out

This paper develops a light-based method to modulate cardiomyocyte beating rate using near-infrared plasmonic heating and measures local temperature changes with silica-coated quantum dots.

Immunologically mediated trade-offs shaping transmission of sylvatic dengue and Zika viruses in native and novel non-human primate hosts

This study investigates immunological trade-offs in non-human primate hosts for dengue and Zika viruses, finding that higher viral replication correlates with increased transmission but reduced antibody response.

The novel nematicide chiricanine A suppresses Bursaphelenchus xylophilus pathogenicity in Pinus massoniana by inhibiting Aspergillus and its secondary metabolite, sterigmatocystin

Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal clades

The paper shows that genetic excision of a cardiac troponin I extension in mammals allows for high heart rates by mimicking phosphorylation without adrenergic stimulation.

Automated whole-organ histological imaging assisted with ultraviolet-excited sectioning tomography and deep learning

This paper introduces HistoTRUST, a pipeline combining ultraviolet-excited sectioning tomography and deep learning to rapidly generate 3D histological images of whole organs.

Analytical Comparability to Evaluate Impact of Manufacturing Changes of ARX788, an Anti-HER2 ADC in Late-Stage Clinical Development

The paper evaluates the impact of manufacturing changes on ARX788, an anti-HER2 ADC, using ICH Q5E guidelines and shows no adverse effect on product quality.

The Ralstonia pseudosolanacearum effector RipE1 is recognized at the plasma membrane by NbPtr1, Nicotiana benthamiana homolog of Pseudomonas tomato race 1.

This study identifies NbPtr1 as the receptor recognizing the Ralstonia pseudosolanacearum effector RipE1 in Nicotiana benthamiana, showing membrane association and polymorphism in recognition.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of aging

The paper introduces a Poisson-based model to predict cancer incidence and proposes a theory of aging linked to cellular entropy and resource limits.

Endogenous bystander killing mechanisms enhance the activity of novel FAP-CAR-T cells against glioblastoma

This study shows FAP-CAR-T cells effectively kill glioblastoma cells through bystander mechanisms, even when only some cells express FAP, and demonstrate therapeutic efficacy in vivo.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

Subchronic oral toxicity study of Aldicarb sulfoxide in Sprague-Dawley rats

This study examines the subchronic oral toxicity of Aldicarb sulfoxide in rats, finding liver injury and establishing safety thresholds for exposure.

Chemoenzymatic Measurement of Cell-surface Glycan in Single-cell Multiomics: LacNAc as an Example

The paper introduces a chemoenzymatic method to detect cell-surface glycan in single-cell multiomics, showing increased LacNAc in activated CD8+ T cells and its correlation with glycolytic activity.

Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone