The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration
S. HE, C. V. Carman, J. H. Lee, B. Lan, S. Koehler, L. Atia, C. Y. Park, J. H. Kim, J. A. Mitchel, J.-A. Park, J. P. Butler, S. W. Lee, J. Fredberg
This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.
bioRxiv · Jul 30, 2018Cancer Biology