J. H. Kim

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

This study identifies SARS-CoV-2 NSP13 as a suppressor of Hippo-YAP signaling by interacting with TEAD and remodeling chromatin to inhibit YAP transcriptional activity.

This study shows that warm temperatures suppress systemic acquired resistance in plants by reducing N-hydroxypipecolic acid biosynthesis, affecting both local and systemic immunity.

The paper shows that ball-milled calcium sulfate microparticles improve alginate hydrogel fabrication by creating more stable suspensions, leading to homogeneous gels with consistent mechanical properties for 3D cell culture.

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

The paper identifies MBsomes as mRNA nanocarriers capable of delivering genes and expresses EGFP when loaded with mRNA.

The paper develops humanized yeast strains expressing human prenyltransferases to study prenylation of diverse CaaX sequences from human and viral proteins.

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

This study shows that hyperglycosylation of prosaposin in tumor DCs leads to immune escape by impairing antigen presentation and T cell activation.

This paper introduces FluoMALDI microscopy, which enhances fluorescence and MALDI imaging by co-crystallizing fluorophores with MALDI matrices, enabling simultaneous high-resolution imaging of the same tissue sections.

This paper introduces RaMALDI, a method that combines Raman and MALDI imaging on a single tissue section to integrate molecular information from both modalities.

The paper presents the first ambient temperature crystal structure of Escherichia coli CyaY, revealing an alternate conformation and highlighting temperature's impact on protein structure.

This study shows that de novo fatty-acid synthesis via ACC1 prevents iNKT cell death and promotes their pathogenic roles in allergic asthma.

The paper identifies a novel imidazolium antibiotic from Bacillus licheniformis and proposes its biosynthetic pathway through various experimental methods.

This study demonstrates a non-invasive cancer detection method using C. elegans chemotaxis to canine urine, achieving 85% sensitivity and 93% specificity for common canine cancers.

This study uses untargeted metabolomics to analyze exogenous chemicals in human milk and finds they are present in newborn stool, indicating potential infant exposure through breastfeeding.

This paper uses linear regression with NMR and MD simulation data to determine ensemble structures of Alzheimer's Aβ monomers, revealing β-sheet and partially-helical conformations and their implications for amyloidogenesis.

This study corrects COL7A1 mutations in RDEB patient fibroblasts using base and prime editing, restoring C7 expression and function in vitro and in vivo.

This study shows that ROCK1 is essential for glucose-stimulated insulin secretion in β-cells and regulates pyruvate kinase signaling.

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

This study demonstrates that prime editing can correct disease-causing mutations in adult mouse liver and retina, with minimal off-target effects.

This study uses deep learning to identify stiffness markers in breast cancer tissue, finding that straight collagen percentage best correlates with tissue stiffness.

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

The paper evaluates a new silicone airway stent (GINA stent) in pigs, showing improved mechanical properties and comparable performance to the Dumon stent.

This study identifies novel fusion genes in human angiosarcomas and canine hemangiosarcomas, showing convergent transcriptional programs driven by these fusions and mutations in TP53 and PI3K/AKT/mTOR pathway genes.

This paper develops a rapid tracheal stenosis model in pigs using cuff overpressure and electrocautery, achieving stenosis in 7 days with combined treatment.

This study shows that S100A8/A9 mediates the reprogramming of normal mammary epithelial cells by dynamic interactions with breast cancer cells, leading to epithelial-mesenchymal transition and altered cellular behaviors.

This study shows adolescent female rats in estrous phases with high estradiol levels show delayed fear extinction compared to males and ovariectomized females.

The paper determines the 3D structure and dynamics of P1, a silencing suppressor from Rice Yellow Mottle virus, revealing structural features and their roles in viral infectivity.

This study shows HSV, ACV, and IVIG independently cause sex-biased gut dysbiosis in mice, with ACV reducing protective bacterial taxa linked to GVHD prevention in HSCT patients.