Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways
R. Toy, P. Pradhan, V. Ramesh, N. C. Di Paolo, B. Lash, J. Liu, E. L. Blanchard, P. J. Santangelo, D. M. Shayakhmetov, K. Roy
This study shows modifying primary amines to higher order amines reduces toxicity of cationic nanocarriers by targeting TLR4 and complement pathways in vivo.
bioRxiv · May 24, 2019Bioengineering