Author

R. Toy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:flow cytometry· 1

Frequent Co-Authors

K. Roy· 4 shared D. M. Shayakhmetov· 3 shared P. Pradhan· 3 shared E. L. Blanchard· 2 shared J. Liu· 2 shared P. J. Santangelo· 2 shared A. Atalis· 1 shared A. Larsen· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBioengineering

K. Roy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

R. Toy, M. C. Keenum, P. Pradhan, K. Phang, P. Chen, C. Chukwu, A. Nguyen, J. Liu, S. Jain, G. Kozlowski, J. Hosten, M. Suthar, K. Roy

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

bioRxiv · Jul 17, 2020Bioengineering

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

P. Pradhan, R. Toy, N. Jhita, E. L. Blanchard, A. Atalis, B. Pandey, P. J. Santangelo, D. M. Shayakhmetov, K. Roy

This study identifies TRAF6-IRF5 kinetics and TRIF signaling as key drivers of synergistic innate immune responses to MPLA-CpG co-presentation in BM-APCs.

bioRxiv · Jul 17, 2020Immunology

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

M. Suresh, W. Lee, B. Kingstad-Bakke, B. Paulson, A. Larsen, K. Overmyer, C. Marinaik, K. Dull, R. Toy, G. Vogel, K. Mueller, K. Tweed, A. Walsh, J. Russell, K. Saha, , K. Roy

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

bioRxiv · May 8, 2020 · PreprintImmunology

Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways

R. Toy, P. Pradhan, V. Ramesh, N. C. Di Paolo, B. Lash, J. Liu, E. L. Blanchard, P. J. Santangelo, D. M. Shayakhmetov, K. Roy

This study shows modifying primary amines to higher order amines reduces toxicity of cationic nanocarriers by targeting TLR4 and complement pathways in vivo.

bioRxiv · May 24, 2019Bioengineering