K. Roy

Foci, waves, excitability : self-organization of phase waves in a model of asymmetrically coupled embryonic oscillators

This paper develops a phase model to explain self-organized concentric wave patterns in embryonic oscillators, showing that excitability and coupling function shape these patterns.

Multi-Niche Human Bone Marrow On-A-Chip for Studying the Interactions of Adoptive CAR-T Cell Therapies with Multiple Myeloma

This study develops a 3D bone marrow-on-a-chip model to investigate interactions between CAR-T cells and multiple myeloma cells in different niches and assess therapeutic responses.

Tracking of Lineage Mass via Quantitative Phase Imaging and Confinement in Low Refractive Index Microwells

This paper introduces a platform combining quantitative phase imaging and microwell confinement to improve lineage tracking by measuring cell mass.

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.

Ultrasound-Assisted Hydrolysis of Food Waste using Glucoamylase: Statistical Optimization and Mechanistic Analysis with Molecular Simulations

This paper optimizes food waste hydrolysis using glucoamylase and sonication, showing improved sugar yield and reaction kinetics through structural and computational analysis.

A multiadjuvant polysaccharide-amino acid-lipid (PAL) subunit nanovaccine generates robust systemic and lung-specific mucosal immune responses against SARS-CoV-2 in mice

This study develops a mucosal nanovaccine that enhances both systemic and lung-specific immunity against SARS-CoV-2 in mice through intranasal and intramuscular delivery.

A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

This paper develops a scalable, GMP-compatible cell therapy for Dystrophic Epidermolysis Bullosa using CRISPR-corrected iPS cells to generate functional skin grafts.

Single-Cell Epitope-Transcriptomics Reveal Lung Stromaland Immune Cell Response Kinetics to Nanoparticle delivered RIG-I and TLR4 Agonists

This study uses CITE-seq to analyze lung cell responses to nanoparticle-delivered RIG-I and TLR4 agonists, showing early changes in gene expression and cytokine synthesis.

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway

This study shows exogenous DNA activates the cGAS-STING pathway in pancreatic cancer cells, increasing DUOX2 expression and H2O2 production, which may promote an oxidative microenvironment.

Dexamethasone Inhibits Cytokine-Induced, DUOX2-Related VEGF-A Expression and DNA damage in Human Pancreatic Cancer Cells and Growth of Pancreatic Cancer Xenografts

This study shows dexamethasone inhibits cytokine-induced DUOX2 and VEGF-A expression and DNA damage in pancreatic cancer cells and xenografts, but not in cytokine-unresponsive cells.

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

This study shows that nanoparticle-delivered TLR4 and RIG-I agonists enhance immune responses to a SARS-CoV-2 subunit vaccine in mice, with route-specific effects on T and B cell responses.

Metal-binding propensity in the mitochondrial dynamin-related protein 1

This study shows that Drp1 binds Ni2+ ions, which can be used to purify Drp1 but also inhibits its membrane fission activity.

Microbiome divergence of marine gastropod species separated by the Isthmus of Panama

The paper examines how the formation of the Isthmus of Panama influenced microbiomes of marine gastropod species, finding varied effects across host genera and sample types.

Characterizing Human Mesenchymal Stromal Cells Immune Modulatory Potency Using Targeted Lipidomic Profiling of Sphingolipids

This study uses lipidomic profiling to characterize sphingolipids in MSCs from different sources and identifies sex- and stimulation-dependent differences in ceramide levels linked to immune modulatory potency.

Predicting T Cell Quality During Manufacturing Through an Artificial Intelligence-based Integrative Multi-Omics Analytical Platform

The paper develops an AI-based platform to predict T cell quality during manufacturing using multi-omics data and identifies critical process parameters and quality attributes.

Single-Cell Transcriptomic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells

This study uses single-cell RNA-seq and computational models to identify transcriptomic attributes predicting immunomodulatory potency of mesenchymal stromal cells.

Single-Cell RNAseq of Out-of-Thaw Mesenchymal Stromal Cells Shows Striking Tissue-of-Origin Differences and Inter-donor Cell-Cycle Variations

This study compares single-cell transcriptomes of out-of-thaw mesenchymal stromal cells from bone marrow and cord tissue, revealing tissue-of-origin differences and inter-donor cell-cycle variations.

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

This study identifies TRAF6-IRF5 kinetics and TRIF signaling as key drivers of synergistic innate immune responses to MPLA-CpG co-presentation in BM-APCs.

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection

This study investigates the systemic immune response to orthopedic biomaterial-associated infection in rats, finding long-term immune dysregulation and altered cytokine responses.

A Multi-Niche Microvascularized Human Bone-Marrow-on-a-Chip

This paper develops a multi-niche microvascularized human bone-marrow-on-a-chip that mimics the hBM microenvironment and shows the endosteal niche's significant contribution to hBM physiology.

In-vitro and in-vivo Characterization of a Multi-Stage Enzyme-Responsive Nanoparticle-in-Microgel Pulmonary Drug Delivery System

The paper characterizes a nanoparticle-in-microgel system for pulmonary drug delivery, focusing on its in-vitro and in-vivo performance to overcome physiologic barriers in the lungs.

Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways

This study shows modifying primary amines to higher order amines reduces toxicity of cationic nanocarriers by targeting TLR4 and complement pathways in vivo.

Functionalized microcarriers improve T cell manufacturing by facilitating migratory memory T cell production and increasing CD4/CD8 ratio

This study introduces functionalized microcarriers that enhance T cell expansion, increase migratory memory T cell production, and improve the CD4/CD8 ratio compared to current methods.

Effects of BMP-2 dose and delivery of microvascular fragments on healing of bone defects with concomitant volumetric muscle loss

This study tests the effect of BMP-2 dose and co-delivery of microvascular fragments on healing of bone defects with muscle loss, finding dose-dependent bone regeneration without heterotopic ossification.