P. Pradhan

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

This study shows that nanoparticle-delivered TLR4 and RIG-I agonists enhance immune responses to a SARS-CoV-2 subunit vaccine in mice, with route-specific effects on T and B cell responses.

How synonymous mutations alter enzyme structure andfunction over long time scales

This paper shows that synonymous mutations alter enzyme function over time by causing misfolded, entangled protein states that reduce catalytic activity.

Single-Cell Transcriptomic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells

This study uses single-cell RNA-seq and computational models to identify transcriptomic attributes predicting immunomodulatory potency of mesenchymal stromal cells.

Single-Cell RNAseq of Out-of-Thaw Mesenchymal Stromal Cells Shows Striking Tissue-of-Origin Differences and Inter-donor Cell-Cycle Variations

This study compares single-cell transcriptomes of out-of-thaw mesenchymal stromal cells from bone marrow and cord tissue, revealing tissue-of-origin differences and inter-donor cell-cycle variations.

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

This study identifies TRAF6-IRF5 kinetics and TRIF signaling as key drivers of synergistic innate immune responses to MPLA-CpG co-presentation in BM-APCs.

Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag

The paper identifies four unique inserts in the 2019-nCoV spike protein that show similarity to HIV-1 gp120 and Gag, suggesting potential evolutionary links and implications for viral function and diagnosis.

Development of Systemic Immune Dysregulation in a Rat Trauma Model with Biomaterial-Associated Infection

This study investigates the systemic immune response to orthopedic biomaterial-associated infection in rats, finding long-term immune dysregulation and altered cytokine responses.

Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways

This study shows modifying primary amines to higher order amines reduces toxicity of cationic nanocarriers by targeting TLR4 and complement pathways in vivo.