ImmunologybioRxiv
Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden
N. J. Parekh, T. E. Krouse, I. E. Reider…·C. C. Norbury
The paper shows that T1-IFN produced by a subset of VACV-infected cells via the cGAS/STING pathway protects mice by recruiting inflammatory monocytes, independent of viral replication.
DOI 10.1371/journal.ppat.1007778