Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen
J. Bass, B. Marcheva, B. J. Weidemann, A. Taguchi, M. Perelis, K. M. Ramsey, M. V. Newman, Y. Kobayashi, C. Omura, J. E. Manning Fox, H. Lin, P. E. Macdonald
The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.
bioRxiv · Nov 5, 2021Cell Biology