Author

A. Taguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cell Biology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Walker· 2 shared A. J. Perez· 1 shared B. J. Weidemann· 1 shared B. Marcheva· 1 shared C. Omura· 1 shared D. Kahne· 1 shared E. E. Carlson· 1 shared H. Lin· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

S. Walker

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Structural basis of nucleotide selectivity in pyruvate kinase

A. Taguchi, R. Nakashima, K. Nishino

This study presents crystal structures of Streptococcus pneumoniae PYK bound to nucleotides, revealing structural basis for GTP selectivity and its role in nucleotide homeostasis.

bioRxiv · Jun 25, 2024Biochemistry

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

J. Bass, B. Marcheva, B. J. Weidemann, A. Taguchi, M. Perelis, K. M. Ramsey, M. V. Newman, Y. Kobayashi, C. Omura, J. E. Manning Fox, H. Lin, P. E. Macdonald

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

bioRxiv · Nov 5, 2021Cell Biology

Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall

A. Taguchi, S. Walker

This study identifies MpgA and MpgB as muramidases in Streptococcus pneumoniae and shows they cleave peptidoglycan at different positions, with MpgA's activity regulated by a LysM-like domain.

bioRxiv · Mar 6, 2021Microbiology

Organization of Peptidoglycan Synthesis in Nodes and Separate Rings at Different Stages of Cell Division of Streptococcus pneumoniae

A. J. Perez, M. J. Boersma, K. E. Bruce, M. M. Lamanna, S. L. Shaw, H.-C. T. Tsui, A. Taguchi, E. E. Carlson, M. S. VanNieuwenhze, M. E. Winkler

This paper investigates the spatial organization of peptidoglycan synthesis in Streptococcus pneumoniae during cell division, revealing distinct rings and nodes of transpeptidase activity and PBP localization.

bioRxiv · Sep 27, 2020Microbiology

Association between Japanese community health workers willingness to continue service and two categories of motives: altruistic and self-oriented

A. Taguchi, H. Murayama, K. Ono

This study examines how altruistic and self-oriented motives influence Japanese community health workers' willingness to continue service, finding both motives positively affect retention with altruistic motives having a slightly stronger effect.

bioRxiv · Jul 15, 2019Scientific Communication & Education

FtsW is a peptidoglycan polymerase that is activated by its cognate penicillin-binding protein

A. Taguchi, M. A. Welsh, L. S. Marmont, W. Lee, D. Kahne, T. G. Bernhardt, S. Walker

This study identifies FtsW as a peptidoglycan polymerase that requires its cognate class B PBP for activity and is essential for septal cell wall synthesis during bacterial division.

bioRxiv · Jun 29, 2018Microbiology