P. E. MacDonald

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

This study describes an all-stages complete suspension protocol for generating functional pancreatic islets from human pluripotent stem cells using Vertical Wheel bioreactors.

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

This study uses calcium imaging to compare calcium oscillations, waves, and network dynamics in human islets from donors with and without type 2 diabetes, finding altered glucose responses and network structure in diabetic islets.

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

This study finds that the rs3842753 C allele is associated with higher INS mRNA and ER stress in beta cells, suggesting a link between genetic variation and beta cell dysfunction in type 1 diabetes.

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

This study identifies NFIA as a regulator of granule recruitment and exocytosis in pancreatic cells, showing its role in insulin and enzyme secretion and linking it to metabolic disorders.

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.