Human proton channels accumulate in cholesterol dependent membrane domains via direct interaction with stomatin
A. G. Ayuyan, V. V. Cherny, G. Chaves, B. Musset, F. S. Cohen, T. E. DeCoursey
This paper investigates how cholesterol affects the human voltage-gated proton channel hHV1, finding that cholesterol influences H+ currents in excised patches but not whole-cell configurations, suggesting indirect effects via cholesterol-dependent lipid domains.
bioRxiv · Sep 28, 2023 · PreprintPhysiology