Author

D. Boytsov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electrophysiology· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:deep learning· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Rudnick· 2 shared M. Freissmuth· 2 shared W. Sandtner· 2 shared A. Basbaum· 1 shared A. Elkasaby· 1 shared A. Kasture· 1 shared A. Manglik· 1 shared A. Seth· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

G. Rudnick

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of the potassium binding site in serotonin transporter SERT

E. Hellsberg, D. Boytsov, Q. Chen, M. Niello, M. Freissmuth, G. Rudnick, Y.-W. Zhang, W. Sandtner, L. R. Forrest

This study identifies the Na2 site as the potassium binding site in SERT using molecular dynamics simulations and site-directed mutagenesis.

Proceedings of the National Academy of Sciences · Apr 23, 2024Peer-reviewedBiochemistry

A mechanism of uncompetitive inhibition of the serotonin transporter

S. Bhat, A. Elkasaby, A. Kasture, D. Boytsov, J. B. Reichelt, T. Hummel, S. Sucic, C. Pifl, M. Freissmuth, W. Sandtner

This paper identifies ECSI#6 as an uncompetitive inhibitor of the serotonin transporter, showing it preferentially binds to the K+-bound inward-facing conformation and acts as a pharmacochaperone for misfolded variants.

bioRxiv · Aug 11, 2022Pharmacology & Toxicology

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle, J. Braz, R. M. Rodriguiz, K. Roy, B. Bekele, V. Craik, X.-P. Huang, D. Boytsov, P. Lak, H. R. O'Donnell, W. R. Sandtner, B. L. Roth, A. Basbaum, , G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

bioRxiv · Jun 13, 2022Biochemistry

Trapped pore waters in the open proton channel HV1

D. Boytsov, S. Brescia, G. Chaves, S. Koefler, C. Hannesschlaeger, C. Siligan, N. Goessweiner-Mohr, B. Musset, P. Pohl

The paper investigates proton transport through HV1 channels, finding that water is trapped in the pore and that H+ conductance is reduced by removing a charged amino acid.

bioRxiv · May 9, 2022Biophysics