Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria
R. Grinter, B. Ney, R. Brammananth, C. K. Barlow, P. R. F. Cordero, D. L. Gillett, T. Izore, M. Cryle, L. Harold, G. M. Cook, G. Taiaroa, D. A. Williamson, A. C. Warden, J. G. Oakeshott, M. C. Taylor, , C. Greening
This study resolves the biosynthesis pathway of F420 in mycobacteria by showing phosphoenolpyruvate, not 2-phospholactate, is the precursor and identifies the structural mechanism of dehydro-F420-0 production.
bioRxiv · Feb 27, 2020Biochemistry