G. M. Cook

This paper describes the discovery of a marine sponge-associated mycobacterium closely related to M. tuberculosis, which shares virulence factors but lacks virulence in mice.

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

This paper identifies the CroRS two-component system as a regulator of isoprenoid biosynthesis in Enterococcus faecalis, linking it to antimicrobial tolerance through cell envelope maintenance.

This paper determines the structure of a mycobacterial hydrogenase and explains how it selectively oxidizes atmospheric H2 while avoiding O2, enabling energy extraction from air.

The paper investigates protein transport through the Sec-machinery, finding that arginine diffusion limits transport and PMF contributes via a proton ratchet mechanism.

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

This paper shows that reducing RNase HI activity in mycobacteria increases sensitivity to rifampicin, suggesting RNase HI as a target for new antibiotics.

This study shows that impaired succinate oxidation in M. tuberculosis prevents growth and affects drug susceptibility by altering respiratory chain activity and drug responses.

This study evaluates novel oral tuberculosis regimens containing TB47, clofazimine, and linezolid, showing fast-acting sterilizing activity and no relapse in a mouse model.

This paper investigates the unfolded protein response (UPR) in coronavirus infection and shows that pharmacological inhibition of the UPR significantly reduces viral replication.

This study resolves the biosynthesis pathway of F420 in mycobacteria by showing phosphoenolpyruvate, not 2-phospholactate, is the precursor and identifies the structural mechanism of dehydro-F420-0 production.

This study identifies two hydrogenases in Mycobacterium smegmatis that differentially interact with the respiratory chain during growth and persistence, performing distinct roles under varying conditions.

This paper traces the dispersal of Mycobacterium tuberculosis lineage 4.4 strains in New Zealand and Canada using genomic data, linking their spread to historical European trade and migration.