Author

M. Cryle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. C. Warden· 1 shared B. Ney· 1 shared C. Greening· 1 shared C. J. Jackson· 1 shared C. K. Barlow· 1 shared D. A. Williamson· 1 shared D. L. Gillett· 1 shared D. Mouradov· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. C. Warden

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2 papers

Recent·Most cited

SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss

X. Xi, L. Liu, N. Tuano, J. Tailhades, D. Mouradov, O. Sieber, M. Cryle, E. Segelov, J. Rosenbluh

The paper identifies SRP19 as a vulnerability in cancers with APC loss, showing that reducing SRP19 inhibits proliferation through ER stress.

bioRxiv · Jan 30, 2024 · PreprintCancer Biology

Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria

R. Grinter, B. Ney, R. Brammananth, C. K. Barlow, P. R. F. Cordero, D. L. Gillett, T. Izore, M. Cryle, L. Harold, G. M. Cook, G. Taiaroa, D. A. Williamson, A. C. Warden, J. G. Oakeshott, M. C. Taylor, , C. Greening

This study resolves the biosynthesis pathway of F420 in mycobacteria by showing phosphoenolpyruvate, not 2-phospholactate, is the precursor and identifies the structural mechanism of dehydro-F420-0 production.

bioRxiv · Feb 27, 2020Biochemistry