Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction
B. Meng, N. Zhao, P. Mlcochova, I. Ferreira, B. Ortmann, T. Davis, J. Rehwinkle, S. Cook, P. Maxwell, J. Nathan, R. K. Gupta
This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.
bioRxiv · Dec 15, 2023 · PreprintCell Biology