R. K. Gupta

This study investigates how N354 glycosylation in the SARS-CoV-2 spike protein affects viral fitness and human adaptation through multiple mechanisms.

The paper shows that CD4 T cell contact induces macrophage cell cycle progression from G0 to G1, increasing their susceptibility to lentiviral transduction.

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

This study shows that GPR84 promotes brown adipocyte function by regulating mitochondrial calcium and respiration, with implications for metabolic disease treatment.

This study shows that cyclin D3 depletion during SARS-CoV-2 infection enhances virus titres and is independent of cell cycle arrest, suggesting a role in restricting viral assembly.

This study examines how mutations in the SARS-CoV-2 Spike N-Terminal Domain affect viral entry and fusogenicity, showing context-dependent modulation of spike function.

This study investigates the origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 (Alpha) in the UK, finding that a chronically-infected immunocompetent individual likely drove its rapid mutation and spread.

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

This study uses digital holographic microscopy and deep learning to classify CD4+ and CD8+ T cells with high throughput and accuracy.

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

The paper shows that macaques improve joint-action performance when cued about future collaborative actions, indicating a 'we-representation' in collective behavior.

This study evaluates how Spike mutations in SARS-CoV-2 variants affect neutralization by monoclonal and polyclonal antibodies, showing reduced activity in some cases.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This paper identifies a recurrent SARS-CoV-2 Spike deletion (H69/V70) that increases infectivity and compensates for RBD mutations, suggesting it may facilitate immune escape and variant emergence.

This study demonstrates that titanium dioxide-coated surfaces can inactivate SARS-CoV-2 under ambient light within 5 hours of exposure.

The paper identifies a novel protease inhibitor resistance signature in HIV-1 matrix through genotypic and phenotypic analysis of patients failing PI therapy.

This study shows TLR4 activation in macrophages induces G0 arrest and SAMHD1 activation independently of IFN, blocking HIV-1 infection through SAMHD1.

This paper evaluates 17 mRNA signatures for predicting incipient tuberculosis using a pooled dataset of 1,026 samples, finding that eight signatures show moderate diagnostic accuracy but fall short of WHO benchmarks for long-term risk prediction.

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.