S. Cook

Operational lessons learned from simulating an elimination response to a transboundary animal disease in wild animals

The paper simulates a TAD control effort in wild pigs to identify operational challenges and propose solutions for rapid population reduction during a hypothetical outbreak.

Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity

What is Known, Unknown, and Needed to be Known about Damage Caused by Wild Pigs

This study reviews wild pig damage assessments, identifies gaps in standardization, and recommends frameworks for quantifying damage and linking it to population density to improve management strategies.

Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

This study identifies non-cell-autonomous and cell-autonomous roles of arginase-II in cardiac aging, showing its impact on inflammation, fibrosis, and ischemic injury through macrophage-derived IL-1β and fibroblast mtROS.

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

Identification of a targetable ST2-expressing fibroblast subset driving Peutz-Jeghers syndrome polyposis

This study identifies ST2-expressing fibroblasts as drivers of Peutz-Jeghers syndrome polyposis and shows IL-11 as a therapeutic target.

Temperature and food chain length, but not latitude, explain region-specific kelp forest responses to an unprecedented heatwave

The paper examines how temperature and food chain length, but not latitude, influence kelp forest responses to a heatwave in British Columbia.

Fibrin, Bone Marrow Cells and macrophages interactively modulate cardiomyoblast fate.

This study shows that fibrin and bone marrow cells reduce cardiac damage and improve function after myocardial infarction by modulating macrophage behavior and promoting cardiomyoblast proliferation.

Interleukin-11 plays a key role in human and mouse alcohol-related liver disease

This study shows IL-11 is elevated in severe liver disease and blocking it reduces inflammation in alcohol-related liver disease in humans and mice.

Interleukin 11 expression causes murine inflammatory bowel disease

This study shows that IL11 secretion from stromal cells drives inflammatory bowel disease in mice, suggesting IL11 as a therapeutic target for inflammatory bowel disease.

Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall

This study examines seed germination strategies of eight arid zone woody plant species, finding that most have non-dormant, rapidly germinating seeds, while some exhibit dormancy to cope with unpredictable rainfall.

Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study

This study uses MRI to compare cardiac fibrosis and function in schizophrenia patients on antipsychotics with healthy controls, finding increased T1 times and reduced cardiac volumes in patients.

In vivo generation of post-infarct mouse cardiac muscle by cardiomyocyte progenitors produced with a reproducible laminin-promoted human stem cell differentiation system

This paper develops a reproducible method to generate cardiac muscle progenitors from human stem cells using laminin-221, which can form human heart muscle in vivo after transplantation.