F. McCaughan

CD98 is critical for a conserved inflammatory response to diverse injury stimuli relevant to IPF exacerbations and COVID pneumonitis

This study identifies CD98 as critical for inflammatory responses to injury stimuli in IPF exacerbations and COVID pneumonitis, showing its role in IL-6 and IL-8 responses and fibrosis progression.

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infection

The paper investigates how cigarette smoke affects ACE2 expression in airway cells and finds it increases full-length ACE2 without increasing SARS-CoV-2 infectivity.

Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

This study evaluates intranasal nafamostat and camostat for preventing SARS-CoV-2 infection in Syrian golden hamsters, finding nafamostat effective in keeping viral RNA undetectable for 7 days.

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated primary human airway cells

This study shows topical camostat mesylate inhibits SARS-CoV-2 infection in human airway cells, suggesting it could be used for pre- or post-exposure prophylaxis.

Identification of SARS-CoV-2 induced pathways reveal drug repurposing strategies

The paper identifies 200 approved drugs that target SARS-CoV-2-induced pathways, with 40 in clinical trials, and classifies them into viral replication and immune response mechanisms.

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

This study identifies BCL11A as an oncogene in lung squamous cell carcinoma, showing its interaction with SOX2 to regulate epigenetic factors and demonstrating potential therapeutic targets.