Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer
S. Kamle, B. Ma, G. Schor, M. Bailey, B. Pham, I. Cho, H. Khan, C. Azzoli, M. Hofstetter, C.-M. Lee, R. Herbst, K. Politi, C. G. Lee, J. A. Elias
This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.
bioRxiv · Sep 21, 2023Cancer Biology