Cancer BiologybioRxiv
Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer
S. Kamle, B. Ma, G. Schor…·J. A. Elias
This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.
DOI 10.1016/j.tranon.2024.102108