M. Bailey

SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

This study examines the impact of SARS-CoV-2 infection on intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized patients, finding associations between specific microbial changes and disease severity.

Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer

This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

Alkalinity modulates a unique suite of genes to recalibrate growth and pH homeostasis

This study identifies pH-sensitive genes in plants grown under varying alkaline conditions and reveals their role in growth and pH homeostasis.

The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecology

The paper uses spatial transcriptomics to analyze Cancer Hallmarks in 63 tumors, revealing spatial patterns of hallmark activity and interdependencies between cancer and tumor microenvironment.

Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells.

The paper identifies and characterizes influenza NP-specific CD8 T cells in porcine tissues, showing their persistence and gene expression changes in the lung.

Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus

The paper analyzes B cell repertoires from SARS-CoV-2, Ebola, and RSV infections to identify distinct anti-viral immune responses and repertoire characteristics.

Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzdiimidazole ligand's rescue of Parkinson's-associated cell toxicity

This paper identifies Rab1a as a target of the compound NAB2, which rescues Parkinson's-associated cell toxicity by restoring ER-to-Golgi trafficking.

Wide distribution of alternatively coded Lak megaphages in animal microbiomes

The paper identifies a wide distribution of alternatively coded Lak phages in animal microbiomes, including new genomes and associations with specific animal types.

Robust integrated intracellular organization of the human iPS cell: where, how much, and how variable

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

The Arabidopsis NOT4A E3 ligase coordinates PGR3 expression to regulate chloroplast protein translation

This study shows that the Arabidopsis NOT4A E3 ligase regulates PGR3 expression, which is essential for chloroplast protein translation and photosynthetic function.

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.

Bacterial physiological adaptations to contrasting edaphic conditions identified using landscape scale metagenomics

The paper identifies bacterial physiological adaptations to soil pH variations using metagenomics, showing functional diversity is not constrained by taxonomy.