C.-M. Lee

MAC3A and MAC3B modulate FLM splicing to repress photoperiod-dependent floral transition

This study shows MAC3A and MAC3B regulate FLM splicing to delay flowering under short-day conditions by modulating gene expression in response to photoperiod.

Chitinase 3-like-1 (CHI3L1) Inhibits Innate Anti-Tumor and Tissue Remodeling ImmuneResponses by Regulating CD47-SIRPα and CD24-Siglec10-Mediated Phagocytosis

This study shows CHI3L1 inhibits macrophage phagocytosis by modulating CD47-SIRPα and CD24-Siglec10 pathways, contributing to immune evasion in cancer and COPD.

Chitinase 3-like-1 (CHI3L1) in the Pathogenesis of Epidermal Growth Factor Receptor Mutant Non-Small Cell Lung Cancer

This study shows CHI3L1 is induced by EGFR activation in NSCLC and promotes EGFR signaling, with anti-CHI3L1 antibodies reversing TKI resistance and inhibiting metastasis.

CHI3L1 Enhances Melanoma Lung Metastasis via Regulation of T cell Co-stimulators and CTLA-4/B7 Axis

This study shows CHI3L1 promotes melanoma lung metastasis by inhibiting T cell co-stimulators and stimulating CTLA-4/B7 axis, with combined anti-CHI3L1 and anti-CTLA-4 antibodies showing synergistic antitumor effects.

High-throughput Production of Diverse Xenobiotic Metabolites with P450-transduced Huh7 Hepatoma Cell Lines

This paper develops P450-expressing Huh7 cell lines to generate xenobiotic metabolites, enabling high-throughput analysis of drug metabolism and identification of specific enzyme-substrate interactions.

Kasugamycin is a novel chitinase 1 inhibitor with strong antifibrotic effects on pulmonary fibrosis

This study identifies Kasugamycin as a novel CHIT1 inhibitor with strong antifibrotic effects in pulmonary fibrosis models.

Chitinase 3-like-1 Stimulates PD-L1 and Other Immune Checkpoint Inhibitors

This study shows Chi3l1 promotes PD-L1 and other immune checkpoint inhibitors in melanoma, suggesting combined targeting of Chi3l1 and PD-1-PD-L1 as a therapeutic strategy for pulmonary metastasis.

Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19

This study identifies CHI3L1 as a key mediator of aging-related severity in COVID-19 by stimulating ACE2 and SPP expression, and shows it is a therapeutic target.

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

Genome-Enabled Discovery of Anthraquinone Biosynthesis in Senna tora

The paper identifies a CHS-L gene responsible for anthraquinone biosynthesis in S. tora using genomics, transcriptomics, metabolomics, and biochemistry.

De novo transcriptome sequence of Senna tora provides insights into anthraquinone biosynthesis

The paper reports the de novo transcriptome of Senna tora using RNA-Seq and Iso-Seq, identifies genes and transcription factors involved in anthraquinone biosynthesis, and shows differential expression across tissue development stages.

GIGANTEA recruits deubiquitylases, UBP12 and UBP13, to regulate accumulation of the ZTL photoreceptor complex

This study shows that GIGANTEA recruits UBP12 and UBP13 to the ZTL complex to stabilize clock proteins during the day.

Decoys provide a scalable platform for the genetic analysis of plant E3 ubiquitin ligases that regulate circadian clock function

The paper uses decoy E3 ubiquitin ligases to identify new regulators of the plant circadian clock, showing redundancy in PUB59 and PUB60's role in gene splicing and circadian period control.