Cholesterol promotes both head group visibility and clustering of PI(4,5)P2 driving unconventional secretion of Fibroblast Growth Factor 2
F. Lolicato, R. Saleppico, A. Griffo, B. Pokrandt, H.-M. Müller, H. Ewers, H. Hähl, J.-B. Fleury, R. Seemann, B. Brügger, K. Jacobs, I. Vattulainen, W. Nickel
This study shows cholesterol enhances FGF2 secretion by promoting PI(4,5)P2 clustering and membrane pore formation.
bioRxiv · Apr 16, 2021Biophysics