K. Jacobs

Macronutrient-preference is modulated by biological sex and estrous cycle in mice

This study shows that female mice consume more fat and spend more time near fat-associated food compared to males, with estrous cycle stage also influencing feeding behavior.

Volatile Organic Compound Specialists in the Phycosphere

The paper identifies VOC-specialist bacteria in diatom cultures and shows their impact on carbon cycling and diatom productivity.

Dual targeting of EZH2 and Histone Deacetylases in hematological malignancies promotes transcriptional and metabolic deregulation leading to ferroptosis

This study shows that targeting EZH2 and HDACs together induces ferroptosis in hematological malignancies by upregulating cholesterol biosynthesis and causing metabolic stress.

Resistance to PSEN1-selective γ-secretase inhibitors in T-cell acute lymphoblastic leukemia

The paper identifies PSEN1 mutations that confer resistance to MRK-560 in T-ALL, revealing three distinct resistance mechanisms.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T cell lymphoma

The paper identifies MYCN overexpression in PTCL and shows EZH2 as a transcriptional co-factor for MYCN-driven gene activation, with therapeutic implications for HDAC inhibitors.

Cholesterol promotes both head group visibility and clustering of PI(4,5)P2 driving unconventional secretion of Fibroblast Growth Factor 2

This study shows cholesterol enhances FGF2 secretion by promoting PI(4,5)P2 clustering and membrane pore formation.

Hydroxyapatite pellets as versatile model surfaces for systematic studies on enamel

This study evaluates hydroxyapatite pellets as a model surface for studying bacterial adhesion, finding similar adhesion properties to enamel under various conditions.

The adhesion capability of S. aureus cells is heterogeneously distributed over the cell envelope

This study measures adhesion strength of S. aureus cells at different positions and finds heterogeneous adhesion profiles explained by distinct adhesive spots.

Characterization of Metarhizium majus (Hypocreales: Clavicipitaceae) isolated from the Western Cape province, South Africa

The paper identifies and verifies the presence of Metarhizium majus in South African soil using morphological and molecular techniques.

Identification of Fis1 interactors in Toxoplasma gondii reveals a novel protein required for peripheral distribution of the mitochondrion.

The paper identifies LMF1 as a novel Toxoplasma gondii protein essential for mitochondrial positioning and morphology during intracellular growth.