Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure
J. M. Francis, D. Leistritz-Edwards, A. Dunn, C. Tarr, J. Lehman, C. Dempsey, A. Hamel, V. Rayon, G. Liu, Y. Wang, M. Wille, M. Durkin, K. Hadley, A. Sheen, B. Roscoe, , D. C. Pregibon
The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.
bioRxiv · Apr 29, 2021 · PreprintImmunology