A. Dunn

Wide-field Intensity Fluctuation Imaging

This paper introduces a method to measure 2D intensity autocorrelation maps using ordinary cameras by modulating illumination with two pulses within a single exposure.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

This study identifies anti-integrin αvβ6 autoantibodies as a predictive biomarker for ulcerative colitis, showing they precede diagnosis by up to 10 years and correlate with adverse outcomes.

Interpreting Inverse Correlation Time: from Blood Flow to Vascular Network

The paper redefines inverse correlation time (ICT) as reflecting both blood flow and vascular network structure, showing ICT sensitivity varies with vessel orientation.

Improved immunoassay sensitivity and specificity using single-molecule colocalization

The paper introduces SiMCA, a method using TIRF microscopy to improve immunoassay sensitivity and specificity by eliminating non-specific background through colocalization of fluorescent signals.

Allelic variation in Class I HLA determines pre-existing memory responses to SARS-CoV-2 that shape the CD8+ T cell repertoire upon viral exposure

The paper characterizes CD8+ T cell responses to SARS-CoV-2 across HLA alleles, showing HLA genotype influences pre-existing immunity and immune repertoire upon viral exposure.

Segmentation-less, automated vascular vectorization robustly extracts neurovascular network statistics from in vivo two-photon images

This paper introduces a segmentation-less method for automated vascular vectorization from in vivo two-photon images, showing improved robustness to image quality compared to intensity-thresholded methods.

Biomimetic sponges improve muscle structure and function following volumetric muscle loss

This study shows that biomimetic sponges improve muscle structure and function in a rodent model of volumetric muscle loss by enhancing myofiber regeneration and reducing fibrosis.

Transmembrane Stem Cell Factor Protein Therapeutics EnhanceRevascularization in Ischemia without Mast Cell Activation

This study develops tmSCF-based therapeutics that enhance revascularization in ischemia without activating mast cells, using proteoliposomes and lipid nanodiscs as delivery systems.

Adhesion-mediated mechanosignaling forces mitohormesis

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

Loss of adipocyte identity through synergistic repression of PPARγ by TGF-β and mechanical stress

The paper shows that TGF-β and mechanical stress together repress PPARγ, causing adipocytes to lose identity and convert into myofibroblasts in a fibrosis model.

Mechanobiological Conditioning of Mesenchymal Stem Cells Enhances Therapeutic Angiogenesis by Inducing a Hybrid Pericyte-Endothelial Phenotype

This study shows that combining mechanical strain and kinase inhibitors enhances mesenchymal stem cells to express pericyte and endothelial markers, improving their angiogenic capabilities.