DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity
S. E. Ochmann, H. Joshi, E. Bueber, H. G. Franquelim, P. Stegemann, B. Sacca, U. F. Keyser, A. Aksimentiev, P. Tinnefeld
The paper develops DNA origami-based voltage sensors with single-molecule sensitivity, showing a 5% FRET change for 100 mV transmembrane potential shifts.
bioRxiv · Aug 18, 2021Biophysics