Author

B. Scheffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Bazarna· 1 shared A. Paschen· 1 shared A. W. Chan· 1 shared A. Zaremba· 1 shared C. K. Kuhn· 1 shared C. Neander· 1 shared C. R. Linnen· 1 shared C. Soun· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. Bazarna

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Author profile →

4 papers

Recent·Most cited

A fully phased, chromosome-scale genome of sugar beet line FC309 enables the discovery of Fusarium Yellows resistance QTL

O. Todd, S. Simpson, B. Scheffler, K. Dorn

The paper presents a chromosome-scale, haplotype-phased genome of sugar beet line FC309 and identifies a QTL for Fusarium Yellows resistance on Chromosome 3.

bioRxiv · May 4, 2024Plant Biology

TERT expression is associated with metastasis from thin primaries, exhausted CD4+ T cells in melanoma and with DNA repair across cancer entities

C. K. Kuhn, J. Meister, S. Kreft, M. Stiller, S.-H. Puppel, A. Zaremba, B. Scheffler, V. Ullrich, T. Schöneberg, D. Schadendorf, S. Horn

This study investigates TERT expression in cancer, finding its association with metastasis, exhausted CD4+ T cells in melanoma, and DNA repair across multiple cancer types.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

Whole-genome resequencing data support a single introduction of the invasive white pine sawfly, Diprion similis

J. S. Davis, S. B. Sim, S. M. Geib, B. Scheffler, C. R. Linnen

The paper uses whole-genome resequencing to show that the invasive white pine sawfly, Diprion similis, was introduced once to North America, with genetic patterns supporting a single population and isolation-by-distance.

bioRxiv · Sep 14, 2022Evolutionary Biology

Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

P. F. Cheung, J. Yang, K. Krengel, K. Althoff, C. Yip, E. H. Siu, L. W. Ng, K. S. Lang, L. Cham, D. R. Engel, C. Soun, I. Cima, B. Scheffler, J. K. Striefler, M. Sinn, , J. T. Siveke

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology