Cancer BiologybioRxivPreprint
Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression
P. F. Cheung, J. Yang, K. Krengel…·J. T. Siveke
This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.
DOI 10.1101/2021.02.24.432700