Author

M. Sinn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Bazarna· 1 shared A. Paschen· 1 shared A. W. Chan· 1 shared B. Scheffler· 1 shared C. Neander· 1 shared C. Soun· 1 shared C. Yip· 1 shared D. Funck· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Bazarna

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2 papers

Recent·Most cited

Guanidine Production by Plant Homoarginine-6-hydroxylases

D. Funck, M. Sinn, G. Forlani, J. S. Hartig

The paper identifies plant enzymes that produce guanidine from homoarginine, showing increased levels in Arabidopsis and suggesting a new role in the nitrogen cycle.

bioRxiv · Aug 22, 2023Biochemistry

Progranulin promotes immune evasion of pancreatic adenocarcinoma through regulation of MHCI expression

P. F. Cheung, J. Yang, K. Krengel, K. Althoff, C. Yip, E. H. Siu, L. W. Ng, K. S. Lang, L. Cham, D. R. Engel, C. Soun, I. Cima, B. Scheffler, J. K. Striefler, M. Sinn, , J. T. Siveke

This study shows that tumor-derived progranulin (PGRN) promotes immune evasion in pancreatic ductal adenocarcinoma by reducing MHC class I expression, and blocking PGRN enhances immune response and slows tumor progression.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology