iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis
B. Sieber, F. Lu, S. M. Stribbling, A. G. Grieve, A. J. Ryan, M. Freeman
This study shows that iRhom2 promotes KRAS-driven oncogenesis by enhancing ADAM17-dependent shedding of ERBB ligands through phosphorylation and 14-3-3 protein recruitment.
bioRxiv · Aug 6, 2021Cancer Biology