F. Lu

Dynamic regulation of H2A.Zub and H3K27me3 by ambient temperature in plant cell fate determination

The paper shows that low temperature restores developmental defects in PRC2 mutants by promoting H2A.Zub deposition at embryonic genes, compensating for H3K27me3 loss and silencing these genes for post-germination development.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

Efficient and reproducible generation of human iPSC-derived cardiomyocytes using a stirred bioreactor

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.

Tbx5 maintains atrial identity by regulating an atrial enhancer network

This study shows Tbx5 maintains atrial identity by regulating an atrial enhancer network through chromatin accessibility and looping.

Systematic mining and functional analysis of factors regulating wheat spike development for breeding selection

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

Emodin Combined with Multiple Low-frequency Low-intensity Ultrasound to Relieve Osteomyelitis Through Sonoantimicrobial Chemotherapy

This study combines emodin with low-frequency low-intensity ultrasound to treat osteomyelitis by enhancing antibacterial and anti-biofilm effects through sonoantimicrobial chemotherapy.

Epigenetic Landscape of HIV Infection in Primary Human Macrophage

This study examines the epigenetic changes in HIV-infected primary human macrophages, revealing a unique non-canonical bivalent epigenetic state and active viral transcription despite heterochromatin marks.

Reactivation of Epstein Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites On The Viral Genome

This paper maps RNA polymerase activity during EBV latency and reactivation, finding that CTCF binding sites are key for early bidirectional transcription during reactivation.

Conserved T-cell epitopes predicted by bioinformatics in SARS-COV-2 variants

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis

This study shows that iRhom2 promotes KRAS-driven oncogenesis by enhancing ADAM17-dependent shedding of ERBB ligands through phosphorylation and 14-3-3 protein recruitment.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

Host protease activity on bacterial pathogens promotes complement- and antibiotic-directed killing

The paper shows host protease neutrophil elastase enhances complement- and antibiotic-mediated killing of bacterial pathogens by disrupting their evasion mechanisms.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Molecular basis for Ras suppressor-1 recruitment to focal adhesions and stabilization of consensus adhesome complex

This study determines the structural basis of Rsu-1 interaction with PINCH-1 and its role in forming a consensus adhesome complex essential for focal adhesion assembly.

Dynamic RNA 3' uridylation and guanylation during mitosis

The paper re-analyzes TAIL-seq data to reveal global RNA poly(A) tail terminal modifications during the mitotic cell cycle, suggesting their role in RNA regulation.

Study on thermal insulation of diagonal-braced wood frame wall

The paper investigates the thermal insulation properties of diagonal-braced wood frame walls but was removed due to an error.

Impacts of diets fed after weaning on gut microbiota and susceptibility to DSS-induced colitis in mice

This study examines how different diets after weaning affect gut microbiota and susceptibility to DSS-induced colitis in mice, finding that high protein diets worsen colitis while high fiber diets reduce it.

Comparative Population Genomics of Bread Wheat (Triticum aestivum) Reveals Its Cultivation and Breeding History in China

This study uses genome-wide resequencing of wheat landraces and cultivars to trace the genetic diversity and breeding history of bread wheat in China.

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

This study shows that EPAC1 promotes ANXA2 translocation to endothelial cell surfaces, enhancing plasminogen to plasmin conversion and fibrinolysis.